来源:bwin必赢国际 发布时间:2020-04-29
一、基本情况介绍
周进,博士/博士后,教授,泰山学者,鸢都学者,bwin必赢国际副院长,博士生导师,山东省优秀研究生指导教师,连续4年入选全球前2%顶尖科学家榜单,美国化学会会员,省医学会会员,山东省高等学校优秀青年创新团队“化学生物学与药学分析创新团队”带头人,山东省高等学校“分子诊疗与高端制剂工程研究中心”主任,“潍坊市肿瘤药物化学生物学重点实验室”主任;2016年于中国科学院化学研究所(活体分析化学重点实验室)获理学博士学位(导师:马会民研究员),中科院优秀毕业生,2020年在韩国高丽大学Jong Seung Kim院士课题组完成药物化学生物学博士后训练;校“1258人才工程”学术骨干;参编《光学探针与传感分析》;《Chinese Chemical Letters》青年编委。开展分子探针、诊疗一体化前药及多模式医学成像等研究,以通讯及第一作者在Adv. Mater.、Chem. Sci.、Anal. Chem.、Chem. Comm.等专业期刊上发表SCI论文50余篇,高被引2篇,封面6篇;授权发明专利3件。
【联系方式】E-mail: zhoujin@sdsmu.edu.cn
二、教学工作
承担本科生、留学生、研究生《分析化学》及《仪器分析》教学工作。
三、科研工作
1、主持或参加科研项目(限5项以内)
[1]国家自然科学基金,青年项目,21705120,靶向与检测肿瘤亚细胞结构中氧化还原活性物种的长波长荧光探针的构建及其生物成像分析应用,2018-01至2020-12,24万元,主持
[2]泰山学者人才项目,2022-07至2025-06,135万元,主持
[3]山东省自然科学基金,面上项目,脂滴靶向近红外荧光探针的设计及在肾透明细胞癌诊疗中的应用,2024-01至2026-12,10万元,主持
[4]山东省高等学校优秀青年创新团队“化学生物学与药学分析创新团队”,2019KJM008,新型荧光探针的肿瘤诊疗研发创新,2019-10至2024-01,15万元,主持
[5]北京分子科学国家研究中心,开放课题,BNLMS201812,线粒体靶向近红外分子荧光探针的构建及其应用于帕金森症诊断研究,2018-09至2020-08,8万元,主持
2、代表性论著
[1] Jin Zhou, Paramesh Jangili, Subin Son, Myung Sun Ji, Miae Won, and Jong Seung Kim*, Fluorescent Diagnostic Probes in Neurodegenerative Diseases, Adv. Mater., 2020, 2001945 (封面论文)
[2] Junlan Zhang, Weina Han, Xucong Zhou, Xiao Zhang, Huamei Zhang, Ting Li, Jinling Wang*, Yang Yuan, Yongrui He, and Jin Zhou*, A Lipid Droplet-Specific NIR Fluorescent Probe with a Large Stokes Shift for In Vivo Visualization of Polarity in Contrast-Induced Acute Kidney Injury, Anal. Chem. 2023, 95, 11785–11792. (封面论文)
[3] Xiaoxiao Zhang, Zhenni Wang, Hao Chu, Zuping Xiong, Yanjiang Li, Yi Chen, Qiaozhi Zhu, Hui Feng, Engao Zhu, Jin Zhou,* Peng Huang,* and Zhaosheng Qian*, Antipermeability Strategy to Achieve Extremely High Specificity and Ultralong Imaging of Diverse Cell Membranes Based on Restriction-Induced Emission of AIEgens, Anal. Chem. 2022, 94, (9), 4048–4058.
[4] Jin Zhou, Wen Shi*, Lihong Li, Qiuyu Gong, Xiaofeng Wu, Xiaohua Li, and Huimin Ma*, Detection of misdistribution of tyrosinase in melanosomes and lysosomes and its upregulation under psoralen/ultraviolet A with a melanosome-targeting tyrosinase fluorescent probe. Anal. Chem. 2016, 88, 4557-4564.
[5] Jin Zhou, Lihong Li, Wen Shi,* Xinghui Gao, Xiaohua Li and Huimin Ma*, HOCl can appear in the mitochondria of macrophages during bacterial infection as revealed by a sensitive mitochondrial-targeting fluorescent probe. Chem. Sci. 2015, 6, 4884-4888.
[6] Jin Zhou and Huimin Ma*. Design principles of spectroscopic probes for biological applications. Chem. Sci., 2016, 7, 6309-6315.
[7] Liyuan Sun,‡ Mengfei Zou,‡ Longjie Du,‡ Shugang Wang, Ru Ding, Keliang Lu,* Jianchun Lia and Jin Zhou*, A mitochondria-targeted far-red AIE fluorescent probe for distinguishing between mitophagy and ferroptosis in cancer cells, Chem. Commun., 2023, 59, 12735-12738.
[8] Bochao Chen,‡ Shumei Mao,‡ Yanyan Sun, Liyuan Sun, Ning Ding, Chengde Li* and Jin Zhou*, A mitochondria-targeted near-infrared fluorescent probe for imaging viscosity in living cells and a diabetic mice model, Chem. Commun., 2021, 57, 4376–4379. (封面论文)
[9] Bochao Chen, Chengde Li, Jie Zhang, Jianfei Kan, Tiantian Jiang, Jin Zhou* and Huimin Ma, Sensing and imaging of mitochondrial viscosity in living cells using a red fluorescent probe with a long lifetime, Chem. Commun., 2019, 55, 7410-7413.
[10] Chenxia Zhang, Hai Xie, Tongxia Zhan, Jie Zhang, Bochao Chen, Zhaosheng Qian, Guanglu Zhang, Weifen Zhang and Jin Zhou*, A new mitochondrion targetable fluorescent probe for carbon monoxide-specific detection and live cell imaging, Chem. Commun., 2019, 55, 9444-9447. (封面论文)
3、授权发明专利(限5项以内)
[1]一种检测三光气的荧光探针及其合成方法、试纸及其制备方法和应用,2024-3-21,中国,1/4,ZL202210538117.X.
[2]一种化合物、其合成方法和利用该化合物制成的试剂盒及其在谷胱甘肽检测中的应用,2021-08-20,中国,1/3,ZL201710913339.4.
[3]一种用于检测羧酸酯酶的荧光探针及其制备方法与专用检测试剂盒,2022-02-15,中国,1/4,ZL201811339695.0.
4、获得学术奖励(限5项以内)
[1]泰山学者青年专家,2022.
[2]肿瘤分子荧光探针的设计及其在临床诊断中的应用,山东省医学科技奖,三等奖,1/6,2021.
[3]面向癌症诊断的荧光探针与原位分析,潍坊市自然科学奖,二等奖,1/5,2020.
[4]鸢都学者,2021
[5]山东省优秀研究生指导教师,2021