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李法辉

来源:bwin必赢国际    发布时间:2021-03-24

一、基本情况介绍

李法辉,博士研究生,教授,硕士生导师。

二、教学工作

承担《药物化学》《药物合成反应》《天然药物化学》教学工作。

三、科研工作

1、主持或参加科研项目(限5项以内)

[1] 新型活性化合物的可控制备技术分析测试表征及生物活性研究,应用转化项目,2021-122024-12200万元,在研,主持

[2] 水曲柳种子化学成分及其生物活性研究,山东省中医药管理局,山东省中医药科技发展计划项目,2019-102022-10,结题,主持

[3] 系列药物中间体的中试及大试工艺研究应用转化项目,2021-122024-12200万元,在研,主持

2、代表性论著(限5项以内)

[1] Qian Wang#, Fahui Li#*, Hekai Yang, Ying Wang, Wenshuo Ding, Fengxu Dai, Liuya Wei, Shuhua Cao*Weiguo Song*; Simultaneous self-supply of H2O2 and GSH-depleted intracellular oxidative stress for enhanced photodynamic/photothermal/ chemodynamic therapy, CHEMICAL COMMUNICATIONS, 2022, 58, 61: 8536-8539

[2] Fahui Li#, Congying Gao#, Xueming Li#, Jiangyun Wang, Yao Zhao, Yu Ke, Ying Liu, Hong-Min Liu, Zhenbo Hu*, Liuya Wei*, Zhe-Sheng Chen*; Jiyuan oridonin A induces differentiation of acute myeloid leukemia cells including leukemic stem-like cells, Frontiers in Pharmacology, 2022,13: 1-13.

[3] Fahui Li#, Lihui Zhang#, Jinhong Feng*, Lei Zhang*; Discovery and SAR analysis of phenylbenzo[d] [1,3] dioxole-based proprotein convertase subtilisin/kexin type 9 inhibitors, Journal of Enzyme Inhibition and Medicinal Chemistry, 2022,13: 2017-2035.

[4]Guo Tiantian#; Song Yiming#; Lu Yinghui; Li Guolin; Liu Tian; Han Wenrong; Song Weiguo; Yang Chuncheng; Li Fahui*; Liu Qingchao*; Total synthesis and anticancer activity of  the natural oleanolic acid bidesmoside saponin, albidoside A, isolated from the roots of Acacia albida, Journal of Chemical Reasearch, 2020, 44(1-2): 42-49.

[5] Li Kaoxue*; Liu Chuanchao; Wang Kang; Ren Yang; Li Fahui*;   Sodium borohydride-nickel chloride hexahydrate in EtOH/PEG-400 as an efficient and recyclable catalytic system for the reduction of alkenes, RSC advances, 2018, 8(14): 7761-7764.

3获得学术奖励(限5项以内)

[1] 万吨级盐酸二甲双胍绿色产业化与国际化的关键技术开发, 山东省科技进步奖, 三等奖, 5/62018.